Swallow this medication whole. Do not crush or chew them or the sustained activity of the drug will be destroyed and the chances of side effects occurring may be increased.

Take as directed, usually twice daily for 7 to 12 weeks. Do not take more or less medication than prescribed. Since this drug can cause sleeplessness at first, it is best not to take near bedtime. It is advised to continue smoking for the first week after starting this drug, until it reaches higher levels in your blood. Do not smoke if using any nicotine products with this drug.

This medication is generally well tolerated. Dry mouth, headache, increased sweating, constipation, anxiety and fatigue may occur. If these effects persist or worsen, notify your doctor.

Before taking bupropion tell your doctor if you have a history of seizures, head injury, brain tumor; heart, liver or kidney disease, an eating disorder or any mental conditions, diabetes or if you have any allergies.

Limit or avoid consumption of alcoholic beverages; alcohol can increase your risk of seizures. Chronic alcohol users who suddenly stop the intake of alcohol while taking bupropion may increase the risk of having seizures. Suddenly stopping certain tranquilizers (e.g., diazepam, chlordiazepoxide) is not recommended because doing so may increase the risk of having seizures. Elderly patients may be more sensitive to the effects of this drug.

Tell your doctor if you are pregnant or plan to become pregnant before taking this drug. This drug is excreted into breast milk.

Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Before taking bupropion tell your doctor of all nonprescription and prescription medications you may use especially MAO inhibitors (e.g., isocarboxazid, phenelzine, tranylcypromine, pargyline, selegiline, furazolidone), levodopa, theophylline, corticosteroids (e.g., prednisone), seizure medications, sedatives, ritonavir, tranquilizers/psychiatric drugs (e.g., chlorpromazine), other antidepressants (e.g., amitriptyline), salicylates (e.g., aspirin, salsalate), isoniazid, chlolinesterase inhibitors (e.g., tacrine, donepezil), morphine, and adrenaline-like drugs (e.g., pseudoephedrine).

Excess caffeine intake can increase the chance of seizures with this drug. Check all nonprescription/prescription drug labels for caffeine.

Take any missed dose as soon as possible but not if it is within 8 hours of the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not "double up" the dose.

Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Keep this and all medications out of the reach of children.